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Treating Uterine Sarcoma
If you've been diagnosed with uterine sarcoma, your cancer care team will discuss your treatment options with you. It's important to weigh the benefits of each treatment option against the possible risks and side effects.
Who treats uterine sarcoma?
Depending on your situation, your cancer care team might include:
- A gynecologist, who specializes in diseases of the female reproductive tract
- A gynecologic oncologist, who specializes in the treatment of cancers of the female reproductive system (including surgery, chemotherapy, targeted drug therapy, hormone therapy, and other medicines to treat cancer)
- A radiation oncologist, who uses radiation to treat cancer
- A medical oncologist, who uses chemotherapy, targeted drug therapy, hormone therapy, immunotherapy, and other medicines to treat cancer
Many other health professionals might be a part of your care as well, including other doctors, nurses, nurse practitioners (NPs), physician assistants (PAs), psychologists, social workers, dietitians, and rehabilitation specialists.
How is uterine sarcoma treated?
Types of treatment for uterine sarcoma include:
Because uterine sarcoma is rare, it has been hard to study it well. Most experts agree that treatment in a clinical trial should be considered for any type or stage of uterine sarcoma when available.
Treatment approaches for uterine sarcoma
A combination of treatments might be used to treat uterine sarcoma. The choice of treatment depends largely on the type and stage of your cancer. Other factors might include your age, your overall health, whether you plan to have children, and your personal preferences.
Making treatment decisions
It’s important to discuss all of your treatment options with your cancer care team so you can make the decision that best fits your needs. This includes talking about the goals and possible side effects of each treatment.
Whether you’re thinking about treatment, getting treatment, or not being treated at all, you can also get supportive care to help with pain and other symptoms.
Take your time to think about all your options. It’s also very important to ask questions if you are unsure about anything.
Questions to ask before treatment for uterine sarcoma
Understanding the diagnosis and choosing a treatment plan
- What are my treatment options?
- What do you recommend and why?
- How much experience do you have treating this type of cancer?
- Are there clinical trials we should consider? How can we find out more about them?
- What would the goal of the treatment be?
- How soon do I need to start treatment?
- Should I get a second opinion? How do I do that?
- What are the chances the cancer comes back with these treatment plans?
- Will the treatment put me into menopause early?
- Will I need hormone replacement therapy after treatment? If so, is it safe? What are the chances my cancer will recur (come back) with these treatment plans?
- Will I be able to have children after my treatment?
- What are my treatment options if I want to have children in the future?
- What will we do if the treatment doesn’t work or if the cancer recurs?
What to expect during treatment
- What should I do to be ready for treatment?
- How long will treatment last? What will it be like?
- How will we know if the treatment is working?
- Will the treatment be given in the hospital, clinic, or at home?
- Do I need to change what I eat during treatment?
- How might treatment affect my daily activities? Can I still work full time?
- Can I exercise during treatment? If so, what kind should I do, and how often?
Side effects and long-term effects
- What risks or side effects are there to the treatments you suggest?
- Which side effects start shortly after treatment and which ones might develop later on?
- Is there anything I can do to help manage or avoid side effects?
- What symptoms or side effects should I tell you about right away?
- Can I have sex during treatment? Will my sex life change after treatment?
- How will treatment affect my ability to have children?
Support and resources
- How can I reach you on nights, holidays, or weekends?
- Who can I talk to if I have questions about costs, transportation or housing, insurance coverage or social support?
- What type of follow-up will I need after treatment?
- Do you know of any local or online support groups where I can talk to other people who have been through this?
Other things to consider
Seeking a second opinion: If time allows, consider getting a second opinion to feel more confident about the treatment plan you choose.
Clinical trials: Clinical trials study new treatments and might offer access to promising options not widely available. They are also how doctors learn better ways to treat cancer. Ask your doctor about clinical trials you might qualify for.
Integrative (holistic) and alternative methods: You might hear about herbs, diets, acupuncture, massage, or other ways to relieve your symptoms or treat your cancer. Integrative (holistic) methods are used along with standard care, while alternative ones are used instead of standard care. Some of these might help with symptoms, but many aren’t proven to work and could even be harmful. Talk with your care team first to make sure anything you're considering is safe and won’t interfere with treatment.
Social and emotional health during treatment
It’s normal to have some anxiety or other emotions during and after cancer treatment. Feeling worried, depressed, or angry can impact your health. It can get in the way of relationships, work, and other aspects of life. Talk to your cancer care team about how you are feeling and coping.
With support from other people, including family, friends, mental health professionals, and other survivors, many people who have gone through cancer can thrive despite the challenges they’ve had to face.
Support through your cancer center
Cancer and its treatment can have a profound effect on how you view yourself and your body. It can also affect how you do certain everyday tasks. These impacts are often greatest during the first year of treatment, but they can be long-lasting for some people.
Many cancer centers have special support programs and services to help people with cancer and their families during treatment and for many years after treatment ends. Reach out to your cancer center for help when you need it. This might include services like counseling, social events, or support groups.
Help getting through cancer treatment
Your cancer care team will be your first source of information and support, but there are other resources for help when you need it.
Hospital- or clinic-based support services can also be an important part of cancer care. This might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help.
The 黑料大湿Posts Cancer Society also has programs and services to help you get through treatment, including rides to treatment, lodging, and more. Contact the ACS cancer helpline for more information.
Choosing to stop treatment or choosing no treatment at all
When treatments have been tried and are no longer controlling your cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.
Choosing not to treat your cancer
Some people might not want to be treated at all, especially if the cancer is advanced. There are many reasons you might decide not to get cancer treatment, but it’s important to talk to your doctors as you make that decision.
Remember that even if you choose not to treat your cancer, you can still get supportive care to help with pain or other symptoms.
Hospice care
People who have advanced cancer who are expected to live less than 6 months may want to consider hospice care. Hospice care is designed to provide the best possible quality of life for people who are near the end of life.
You and your family are encouraged to talk with your cancer care team about hospice care options, which include hospice care at home, a special hospice center, or other healthcare locations.
Nursing care and special equipment can make staying at home a workable option for many families.
The treatment information given here is not official policy of the 黑料大湿Posts Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor might have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask your cancer care team any questions you might have about your treatment options.
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- References
Developed by the 黑料大湿Posts Cancer Society medical and editorial content team with medical review and contribution by the 黑料大湿Posts Society of Clinical Oncology (ASCO).
Boggess JF, Kilgore JE, Tran AQ. Chapter 85: Uterine Cancer. In: Niederhuber JE, Armitage JO, Dorshow JH, Kastan MB, Tepper JE, eds. Abeloff’s Clinical Oncology. 6th ed. Philadelphia, Pa. Elsevier: 2020.
Disis ML, Adams SF, Bajpai J, et al. Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer. J Immunother Cancer. 2023;11(6):e006624.
Dondi G, Porcu E, De Palma A, et al. Uterine Preservation Treatments in Sarcomas: Oncological Problems and Reproductive Results: A Systematic Review. Cancers (Basel). 2021;13(22):5808. Published 2021 Nov 19.
Gaillard S, Secord A. Endometrial stromal sarcomas, related tumors, and uterine adenosarcoma. UpToDate. 2026. Accessed at https://www.uptodate.com/contents/endometrial-stromal-sarcomas-related-tumors-and-uterine-adenosarcoma on February 17, 2026.
Hensley M, Leitao M. Treatment and prognosis of uterine leiomyosarcoma. UpToDate. 2026. Accessed at https://www.uptodate.com/contents/treatment-and-prognosis-of-uterine-leiomyosarcoma on February 17, 2026.
Lewis D, Liang A, Mason T, Ferriss JS. Current Treatment Options: Uterine Sarcoma. Curr Treat Options Oncol. 2024;25(7):829-853.
National Cancer Institute. Uterine Sarcoma Treatment. Accessed at https://www.cancer.gov/types/uterine/hp/uterine-sarcoma-treatment-pdq on February 17, 2026.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Uterine Neoplasms Version 2.2026 – November 14, 2025. Accessed at https://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf on February 17, 2026.
Last Revised: June 9, 2026
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